Interference among deleterious mutations favours sex and recombination in finite populations

Article Abstract:

The fate of modifier alleles that alter the frequency of sex and recombination is tracked to show that background selection against deleterious mutant alleles provides a stochastic advantage to sex and recombination that increases with population size. The increase in genetic variance within finite populations has improved the responses to selection and has generated a substantial advantage to sex and recombination that is insensitive to the form of epistatic interactions between deleterious alleles.

Gene mutations, Gene mutation, Sexual selection in animals, Sexual selection (Natural selection), Allelomorphism, Alleles

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Reconstruction of genetic circuits

Article Abstract:

The complex genetic circuits found in cells are ordinarily studied by analysis of genetic and biochemical perturbations. The inherent modularity of biological components like genes and proteins enables a complementary approach, one can construct and analyze synthetic genetic circuits based on their natural counterparts and such circuits can be used as simple in vivo models to explore the relation between the structure and function of a genetic circuit.

Analysis, Cell research, Cytological research, Genetic research, Reverse engineering

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Rad54 protein promotes branch migration of Holliday junctions

Article Abstract:

A demonstration that Rad54, a Swi2/Snf2 protein, binds HJ-like structures with high specificity and promotes their bidirectional branch migration in an ATPase-dependent manner is presented. In vitro, Rad54 is shown to stimulate DNA pairing of Rad51, a key homologous recombination protein.

Prokaryotes, Protein binding, Recombinant proteins

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