L-type calcium channels and GSK-3 regulate the activity of NF-Atc4 in hippocampal neurons

Article Abstract:

It has been established that there is interplay between the regulated nuclear import and export of NF-ATc4 in hippocampal neurons. This interplay is a novel means by which neuronal Ca2+ signals can control gene expression. Synaptic activity or direct depolarization led to rapid translocation of NF-ATc4 to the nucleus and NF-AT-dependent gene expression, indicating that this pathway can act in parallel with other pathways for transcriptional control by Ca2+.

Calcium channels, Hippocampus (Brain)

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Calcineurin/NFAT signalling regulates pancreatic [beta]-cell growth and function

Article Abstract:

A study shows that mice with [beta]-cell specific deletion of the calcineurin phosphatase regulatory subunit, calcineurin b1 (Cnb1) develop age-dependent diabetes characterized by decreased [beta]-cell proliferation and mass, reduced pancreatic insulin content and hypoinsulinaemia. It is learnt that conditional expression of active nuclear factor of activated T-cellsc1 (NFATc1) in Cnb1-deficient [beta] cells rescues these defects and prevents diabetes.

United States, Health aspects, Diabetes, Diabetes mellitus, Cell proliferation, Pancreatic beta cells, Calcineurin

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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21

Article Abstract:

Two genes, DSCR1 and DYRK1A, are found to lie within the critical region of human chromosome 21 and act synergetically to prevent nuclear occupancy of NFATc transcription factors, which are regulators of vertebrate development. The analysis has suggested that the 1.5-fold increase in dosage of DSCR1 and DYRK1A cooperatively destabilizes a regulatory circuit, leading to reduced NFATc activity and many of the features of Down's syndrome.

Care and treatment, Diagnosis, Causes of, Risk factors, Gene mutations, Gene mutation, Down syndrome, Disease/Disorder overview

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