Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection

Article Abstract:

Lipopolysaccharide-binding protein (LBP) is not needed in vivo for the clearance of lipopolysaccharide (LPS) from the circulation. However, LBP is vital for the rapid induction of an inflammatory response by small volumes of LPS or Gram-negative bacteria. It is also essential for the survival of an interperitoneal Salmonella infection. It was found that the inability of LBP-/- mice to control the multiplication of Gram-negative bacteria over the initial period has significant repercussions for the course of the infection.

Bacterial infections

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Meningitis bacterium is viable without endotoxin

Article Abstract:

The endotoxic activity of lipopolysaccharide, the outer monolayer of the outer membrane of Gram-negative bacteria, has been thought to be essential for bacterial growth. However, new research shows that a mutant of Neisseria meningitidis is viable despite the early blocking of lipid A biosynthesis. The findings could allow new approaches to developing vaccines against N. meninisolation ogitidis and its near relative N. gonorrhoeae.

Neisseria gonorrhoeae, Neisseria meningitidis

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Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

Article Abstract:

It has been established that differentiated human macrophage cultures are very sensitive to acetylcholine and nicotine. This research has identified a parasympathetic anti-inflammatory pathway by which the brain modulates systemic inflammatory responses to endotoxin.

Nicotine, Inflammation, Inflammation mediators, Acetylcholine, Acetylcholine receptors, Vagus nerve

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