Long-term correction of rat model of Parkinson's disease by gene therapy

Article Abstract:

Rat muscle cells were lipofected by a tyrosine hydroxylase expression plasmid and used for intracerebrla transplantation into rat models of Parkinson's disease. The transplanted cells continued to express tyrosine hydroxylase during the six-month duration of the experiment. In addition, the mean contralateral rotations induced by apomorphine decreased significantly by 75% for at least six months after transplantation. These results indicate that transplantation of muscle cells expressing tyrosine hydroxylase can promote a long-term correction of Parkinson's disease in a rat model system.

Care and treatment, Parkinson's disease, Parkinson disease

---

Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer

Article Abstract:

Lysosomal storage in the spleen and liver, associated with mucopolysaccharidosis (Sly syndrome), can be mitigated by gene therapy in mice. A beta-glucuronidase gene is transferred into mutant hematopoietic stem cells through the mediation of a retroviral vector. This results in the low-level, long-term expression of beta-glucuronidase, reducing lysosomal accumulation in the spleen and liver and increasing the life span of the treated mice.

Genetic aspects, Mucopolysaccharidosis, Mucopolysaccharidoses

---

Similar abstracts:

• Abstracts: A Drosophila model of Parkinson's disease. Dead end for neurodegeneration? Parkinson's pathology in a fly
• Abstracts: Biodegradation of oil in uplifted basins prevented by deep-burial sterilization. Bacterial photosynthesis in surface waters of the open ocean
• Abstracts: Making the right connections. Small but mighty timekeepers. Post-expressionist flies
• Abstracts: Inhibition of protein kinase C by alcohols and anaesthetics. Induction of vanilloid receptor channel activity by protein kinase C
• Abstracts: Nobel committee rewards pioneers of development studies in fruitflies. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.