Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

Article Abstract:

The DNA and RNA forms of the human immunodeficiency virus (HIV) were monitored using polymerase chain reaction techniques to determine the latent infection rate of CD4+ lymphocytes. The results showed that HIV is contained in a large number of CD4+ lymphocytes and macrophages throughout the lymphoid system throughout the progression of the disease. In addition, the virus was also associated extracellularly with the follicular dendritic cells, which may contribute to lymphocyte infection.

Development and progression, HIV (Viruses), HIV, AIDS (Disease)

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Peak SIV replication in resting memory CD4(super +) T cells depletes gut lamina propria CD4(super +) T cells

Article Abstract:

A demonstration that peak virus production in gut tissues of simian immunodeficiency virus (SIV)-infected rhesus macaques coincides with peak numbers of infected memory CD4(super +) T cells is presented. The results revealed that SIV exploits a large, resident population of resting memory CD4(super +) T cells in gut-associated lymphatic tissue (GALT) to produced peak levels of virus that directly and indirectly deplete CD4(super +) T cells in the effector arm of GALT.

United States, Science & research, T cells, Simian immunodeficiency virus

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Changes in thymic function with age and during the treatment of HIV infection

Article Abstract:

The ability of the thymus to reconstitute T cells expressing CD4 cell-surfaces antigens, lost during HIV infection, may be affected by age-related involution. Thymic output has been quantified through measurements of the excisional DNA products of TCR-gene rearrangement. Thymic function was found to decline with age, but considerable output is maintained into late adulthood.

HIV infection, HIV infections, Thymus, Thymus gland

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