Mechanism of DNA translocation in a replicative hexameric helicase

Article Abstract:

The crystal structure of the E1protein, a hexameric ring helicase belonging to the AAA family, with the single-stranded DNA discretely bound within the hexamer channel and nucleotides at the subunit interfaces, is presented. Only one strand of DNA passes through the hexamer channel and the DNA-binding hairpins of each subunit form a spiral 'staircase' that sequentially tracks the oligonucleotide backbone, with consecutively grouped ATP, ADP and apo configurations correlating with the height of the hairpin, suggesting a straightforward DNA translocation mechanism.

Translocation (Genetics), DNA binding proteins, Structure, Translocations (Genetics)

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Polarons and confinement of electronic motion to two dimensions in a layered manganite

Article Abstract:

The second family of transition-metal oxides-the layered manganites La(sub 2-2x)Sr(sub 1+2x)Mn2O7-with even more extreme confinement and pseudogap effects are shown using certain experimental tools. The data demonstrates positively that as the charge carriers are attached to polarons, it is difficult to remove them from the planes through vaccum-tunnelling into a conventional metallic tip, as it is for them to move between Mn-rich layers within the material itself.

Usage, Infrared spectroscopy, Transition metal compounds, Chemical properties

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