Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

Article Abstract:

Research is presented concerning the generation of a binding site for HP1 proteins through the selective methylation of histone H3 on lysine 9 in mammalian methyltransferases. The implications for gene silencing are discussed.

Physiological aspects, Mammals, Letter to the Editor, Lysine, Methyltransferases

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Rb targets histone H3 methylation and HP1 to promoters

Article Abstract:

Research describing transcription repression in eukaryotic cell processes is presented. In particular the histone and protein components involved in the repressive functions of the retinoblastoma protein are investigated.

Methods, Cell research, Cytological research, Retinoblastoma

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Reversing histone methylation

Article Abstract:

A latest knowledge about methylation and its control of chromatin function is reviewed and the implications of latest reports indicating that the methylation of histones is a dynamic process are presented. The enzymes that mediate the methylation in certain cases are demonstrated to direct the formation of specific chromatin states and to be responsible for transcriptional regulation.

United States, Science & research, Analysis, Protein structure, Methylation

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