Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

Article Abstract:

The enzyme arginine methylatransferase PRMT6 which catalyses histone H3 arginine 2 (H3R2me2a) was identified to characterize the relationship between H3 lysine 4 (H3K4me3) and H3R2me2a. The findings suggest that mutual antagonism between H3R2 and H3K4 methylation together with MLL-family complexes contribute to the localized patterns of H3H4 tri-methylation of transcriptionally active promoters in mammalian genomes.

Genetic aspects, Arginine, Methylation, Lysine, Methyltransferases, Chemical properties

---

Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase

Article Abstract:

The crystal structure analysis of the Escherichia coli Eubacterial leucyl/phenylalanyl-tRNA protein transferase (LF-transferase) complex with phenyalanyl adenosine (rA-Phe) is described. The protein-based mechanism for peptide-bond formation by LF-transferase was found to be similar to the reverse reaction of the acylation step observed in the peptide hydrolysis reaction by serine proteases.

Escherichia coli, Gene expression, Phenylalanine, Peptide bonds

---

ClpS is an essential component of the N-end rule pathway in Escherichia coli

Article Abstract:

Study is conducted to show that ClpAP-specific adaptor, ClpS, is essential for degradation of N-end rule substrates by ClpAP in bacteria. Through interaction with this signal, ClpS converts the ClpAP machine into a protease with exquisitely defined specificity, ideally suited to regulatory proteolysis.

United States, Proteolysis

Similar abstracts:

• Abstracts: Molecular components of the B-cell antigen receptor complex of the IgM class. Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia
• Abstracts: Compartmentalization of S-RNase and HT-B degradation in self-incompatible Nicotiana. Pillow talk in plants
• Abstracts: Between hope and a hard place. Fungal allies enlisted. Lessons from Italy
• Abstracts: Localization of the gravity field and the signature of glacial rebound. Three-dimensional deformation caused by the Bam, Iran, earthquake and the origin of shallow slip deficit
• Abstracts: Effects of parturition on home ranges and social affiliations of female white-tailed deer. Modeling patch occupancy by forest rodents: Incorporating detectability and spatial autocorrelation with hierarchically structured data

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.