Mitotic spindle organization by a plus-end-directed microtubule motor

Article Abstract:

The dynamic self-organization of spindle poles in mitosis may require kinesin-related motor proteins such as Eg5 derived from Xenopus eggs. In vitro assays for spindle assembly involving Eg5 found that the immunodepletion of this protein influenced spindle formation. In addition, Eg5 was identified as a plus-end-directed microtubule motor protein. These results clarify the role of microtubule motor proteins in cell division and mitosis.

---

Poly(ADP-ribose) is required for spindle assembly and structure

Article Abstract:

The study reported that Poly(ADP-ribose) (PAR) is enriched in the spindle required for spindle function, PAR hydrolysis or perturbation leads to rapid disruption of spindle structure, and hydrolysis during spindle assembly blocks the formation of bipolar spindles. It concluded that PAR is a non-proteinaceous, non-chromosomal component of the spindle required for bipolar spindle assembly and function.

United States, Ribose

---

Experimental and theoretical study of mitotic spindle orientation

Article Abstract:

Spindle orientation is understood as a result of the action of cortical force generators, which has interacted with spindle microtubules and is activated by cortical cues. A simple model is developed that has described asymmetric spindle orientations and has provided a quantitative description of the spindle orientation of adherent cells.

Similar abstracts:

• Abstracts: A mutant of the motor protein kinesin that moves in both directions on microtubules. Self-organization of microtubules and motors
• Abstracts: Deglacial changes in ocean circulation from an extended radiocarbon calibration. Glacial/interglacial variations in atmospheric carbon dioxide
• Abstracts: Genetic structure of fragmented populations of the endangered daisy Rutidosis leptorrhynchoides. Reproductive success in reestablished versus natural populations of a threatened grassland daisy (Rutidosis leptorrhynchoides)
• Abstracts: Motion direction, speed and orientation in binocular matching. Object-based attention determines dominance in binocular rivalry
• Abstracts: UK parties differ on means, not ends. New government, old problems. Not on the agenda

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.