Molecular determinants and guided evolution of species-specific RNA editing
Article Abstract:
The striking variation between species in the recoding of Synaptotagmin I (sytI) is reported. The results support a phylogeny of sytI gene editing spanning more than 250 million years of hexapod evolution and also provide models for the genesis of RNA editing sites through the stepwise addition of structural domains, or by short walks through sequence space from ancestral structures.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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RNA editing and death of motor neurons
Article Abstract:
The defect in the editing of the messenger RNA encoding the GluR2 in the spinal motors neutrons of individuals is presented. The failure to swap an arginine for a glutamine residue will interface with the correct functioning of the glutamate receptors and may be a contributory cause of neuronal death in ALS patients.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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A pentatricopeptide repeat protein is essential for RNA editing in chloroplasts
Article Abstract:
RNA editing is a process of RNA maturation involved in the insertion, deletion or modification of nucleotides. A genetic approach is introduced and the discovery of a gene responsible for the specific RNA editing event in the chloroplast is reported.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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