Mrf4 determines skeletal muscle identity in Myf5: Myod double-mutant mice

Article Abstract:

In vertebrates, skeletal muscle is a model for the acquisition of cell fate from stem cells. Two determination factors of the basic helix-loop-helix myogenic regulatory factor (MRF) family, Myf5 and Myod, are thought to direct this transition because double-mutant mice totally lack skeletal muscle fibers and myoblasts. The findings are contradicting the widely held view that myogenic identity is conferred solely by Myf5 and Myod, and identifies Mrf4 as a determination gene.

United States, Science & research, Genetic aspects, Myogenesis

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A Pax3/Pax7-dependent population of skeletal muscle progenitor cells

Article Abstract:

A new cell population that expresses the transcription factors Pax3 and Pax7, but no skeletal-muscle-specific markers, is identified. This resident Pax3/Pax7-dependent progenitor cell population constitutes a source of myogenic cells of prime importance for skeletal muscle formation, a finding also of potential value in the context of cell therapy for muscle disease.

Care and treatment, Observations, Muscle cells, Muscle diseases, Muscular diseases, Structure

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A cellular cornucopia: Stem cells generate new possibilities for research and therapy

Article Abstract:

Issues concerning stem cells, that can renew themselves, are discussed. The use of stem cells to regenerate damaged tissue is reviewed.

Molecular biology, Stem cells

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