New trick from an old foe

Article Abstract:

Human T-cell leukemia viruses type-I (HLTV-I) and human immunodeficiency viruses type 1 (HIV-1) regulate their own gene expression. Although once thought to be exclusive in retroviruses, deoxyribonucleic acid (DNA) tumor viruses have shown similar characteristics. The only difference is that DNA tumor viruses' order of gene expression is transcriptionally regulated while the same is fully regulated at the post-transcriptional level among HLTV-I and HIV-1. A study of the Us11 gene product of herpes simplex virus type 1 suggests that this type of regulation is not unique to complex retroviruses.

Genetic regulation, DNA viruses, HTLV-I (Virus)

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An elusive soluble suppressor

Article Abstract:

Studies suggest that a certain soluble factor or factors derived from CD8+-bearing T lymphocytes suppresses the replication of HIV. However, efforts to isolate and identify the factor/s have been unsuccessful due to a variety of factors. New research provides evidence that at least one of the factors is lymphokine, a special group of lymphocytes that serve as soluble mediators of immunologic regulation. A search for the identity of the other factors has been launched to provide a greater understanding about HIV pathogenesis.

Lymphokines, Suppressor cells

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Trapped but still dangerous

Article Abstract:

Lymphoid organs provide human immunodeficiency virus (HIV) with the necessary conditions for its growth and progression. HIV bound to follicular dendritic cells retains its infectious ability for CD4+ T cells even in the presence of the antibodies in the germinal centers of lymphoid tissue. Importance of these results in finding effective therapeutic strategies for HIV is discussed.

Physiological aspects, Development and progression, Lymphoid tissue, HIV antibodies

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