Nogo in nerve regeneration

Article Abstract:

Most body tissues can repair themselves following injury, but the brain and spinal cord have little innate capacity for repair. It was hypothesized that axons fail to regenerate as they are inhibited by the adult central nervous system (CNS) environment. Three groups have identified a previously unknown gene, Nogo, encoding inhibitory myelin protein. Full-length Nogo-A protein has the strongest inhibitory activity, however there is no compelling evidence that Nogo-A prevents axons from regenerating.

Nervous system, Nerve regeneration

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Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons

Article Abstract:

Axon-linked electrical activity is necessary to cause the growth of oligodendrocyte precursor cells that will eventually become mature oligodendrocytes. Transfection of axons into rat optic nerves showed that axons regulate the number of oligodendrocytes, which are an important part of the vertebrate central nervous system. Axonal electrical activity probably controls oligodendrocyte proliferation by affecting the secretion of growth factors.

Cell proliferation, Electrophysiology

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Induction of sodium channel clustering by oligodendrocytes

Article Abstract:

The clustering effect of oligodendrocytes on sodium channels along central nervous system axons was evaluated using conditioning layers of either purified optic-nerve oligodendrocytes or astrocytes over purified retinal ganglion cells (RGC) from rats. Results have shown that RGCs developed numerous axonal sodium-channel clusters in vivo. Furthermore, mutant rats deficient in oligodendrocytes develop few axonal sodium-channels in vivo.

Physiological aspects, Astrocytes, Sodium channels, Oligodendroglia, Myelin sheath

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