Optimal serum-free Ex Vivo expansion and activation of T lymphocytes using stemline(super TM) T Cell Expansion Medium
Article Abstract:
Stemline T Cell Expansion Medium (STCEM), developed for optimal cell growth under serum-free conditions, outperforms both serum containing and other commercially available serum-free media. T cells expanded STCEM exhibit rigorous and consistent growth kinetics, maintenance of the proper CD4/CD8 ratio, and both ex vivo and in vivo functionality these characteristics of STCEM make it ideal for the ex vivo expansion of T cells for use in human clinical studies.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
Article Abstract:
Study is conducted to show that selective loss of Smad4-dependent signalling in T cells would lead to spontaneous epithelial cancers throughout the gastrointestinal tract in mice whereas epithelial-specific deletion of the Smad4 gene does not. The findings have important implications for the management of patients with familial juvenile polyposis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Sporadic immunogenic tumors avoid destruction by inducing T-cell tolerance
Article Abstract:
The immunosurveillance, the recognition and elimination of tumours by T cells hypothesis postulates that tumours, if they eventually grow, escaped T-cells recognition by losing immunogenicity. Contrary to the hypothesis, by creating a mouse model, it is shown that immunogenic tumours do not escape their recognition but induce tolerance.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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