Optimality, mutation and the evolution of ageing

Article Abstract:

There are two main theories to explain the ageing process. The first assumes that ageing is the product of the selection for a genotype which maximizes early reproductive and survival performance at the expense of senescent stages. Another explanation regards deleterious mutations,which accumulates at the later, and less selected part of life history, as the main cause of ageing. Evidence for both of these hypotheses exist, and the maincause of ageing has not yet been resolved. What is apparent is that ageing is acomplex, polygenic process which is not likely to be halted by genetic intervention.

Physiological aspects, Evolution (Biology), Evolution, Mutation (Biology), Mutation

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Ageing, fitness and neurocognitive function

Article Abstract:

Metabolic and neuro-chemical functions are indicated to improve in adults with greater aerobic fitness. A study considered whether greater aerobic fitness in adults would lead to selective improvements in executive control processes, such as working memory, planning, scheduling and inhibition. The three measures relying on executive control processes were found to be sensitive to exercise intervention, although the benefits were selective.

Health aspects, Physical fitness, Brain chemistry

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New approaches to old age: To truly understand ageing, we must look beyond the diseases of old age

Article Abstract:

Much biomedical research is aimed at increasing life expectancy although the progress made has not advanced our understanding of ageing. Science policy fails to distinguish research on age-associated diseases from research on the fundamental biology of aging. More attention should be given to the question of why old cells are more vulnerable to disease than young cells.

Medical sciences

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