GABAa receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid
Article Abstract:
The progesterone hormone is converted to 3alpha-OH-5alpha-pregnan-20-one (3alpha,5alpha-THP) in the brain. It acts like a sedative by enhancing GABA function. The symptoms of premenstrual syndrome (PMS) are linked to sharp falls in the circulating levels of progesterone and levels of 3alpha,5alpha-THP. A progesterone-withdrawal paradigm, mimicking PMS in a rat model is reported. It was found that PMS symptoms could be partly attributable to change sin GABAA expression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Combating cholesterol
Article Abstract:
New drugs such as squalestatin and zaragozic acids are developed to treat atherosclerosis, a chronic disease associated with the vascular system. The disease is a fatal one and is caused by high level of cholesterol in the blood serum. The new drugs inhibit the production of cholesterol within a cell, reducing the overall level of cholesterol in the blood. The two new drugs are obtained from the cultures of Sporormiella intermedia and Phoma species.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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