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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

PKC-theta is required for TCR-induced NF-kappa-B activation in mature but not immature T lymphocytes

Article Abstract:

Protein kinase C (PKC)-theta, one of several PKC isoenzymes expressed in T cells, is vital for T-cell antigen receptor (TCR)-mediated T-cell activation. However, it is not required during TCR-dependent thymocyte development. The activation of NF-kappa-B by TCR triggering involves a PKC-theta-dependent upstream signalling pathway that leads to the degradation of I-kappa-B-alpha but is separate from pathways used by TNF and IL-1 receptor family members. It must still be established whether the distinct pathways converge in the activation of elements of the I-kappa-B kinase complex.

Author: Littman, Dan R., Sun, Zuoming, Arendt, Christopher W., Ellmeier, Wilfried, Schaeffer, Edward M., Sunshine, Mary Jean, Gandhi, Leena, Annes, Justin, Petrzilka, Daniela, Kupfer, Abraham, Schwartzberg, Pamela L.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Lymphocyte transformation

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Identification of a major co-receptor for primary isolates of HIV-1

Article Abstract:

The CC-CRK-5 beta-chemokine receptor functions as a co-receptor for the primary macrophage-trophic strains of the human immunodeficiency virus 1 (HIV-1) and acts along with CD4 to enable the entry of the virus into host cells. Cells co-expressing CD4 and CC-CRK-5 are highly susceptible to HIV infection while those co-expressing CD4 and other members of the CC-CRK-5 family are resistant to infection. CC-CRK-5 activates the fusion of plasma membrane with the HIV-1 envelope. Beta-chemokines are cytokines that suppress HIV infection by blocking its entry and replication in cells.

Author: Littman, Dan R., Ellmeier, Wilfried, Schall, Thomas J., Davis, Craig B., Landau, Nathaniel R., Unutmaz, Derya, Liu, Rong, Deng, HongKui, Choe, Sunny, Burkhart, Michael, Di Marzio, Paola, Marmon, Shoshana, Sutton, Richard E., Hill, C. Mark, Peiper, Stephen C.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
Analysis, HIV infection, HIV infections, HIV (Viruses), HIV, Cytokines, Virus receptors

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Selective modulation of protein kinase C-theta during T-cell activation

Article Abstract:

Immunofluorescence microscopy studies suggest that protein kinase C-theta (PKC) plays an important role in T-cell activation. Of six isoforms of protein kinase C in antigen-presenting cell activation (APC) studies, only PKC-theta exhibited selective antigen-dependent translocation to the cell contact. In vitro kinase activity assays of PKC immunoprecipitates from T-cell and APC conjugates showed a selective increase in the activity of PKC-theta indicating that the translocated enzyme is active.

Author: Kupfer, Abraham, Monks, Colin R.F., Kupfer, Hannah, Tamir, Idan, Barlow, Avlin
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
T cells

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Subjects list: Research, Protein kinases
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