Humanized xenobiotic response in mice expressing nuclear receptor SXR

Article Abstract:

A study of mice is presented with reference to the effect of cytochrome CYP3A gene products. The induction of CYP3A is shown to be affected by the nuclear receptors PXR/SXR and may have implications for human xenoprotection.

Observations, Mice, Mice (Rodents), Letter to the Editor, Genetic research

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Role of CBP/P300 in nuclear receptor signalling

Article Abstract:

The CREB-binding protein and its homolog P300 regulate the nuclear-receptor-induced gene transcription. They respond transcriptionally to cyclic AMP, phorbol esters, serum and lipophilic hormones. They serve as the target of the E1A oncoprotein. This response indicates that they integrate extracellular and intracellular signalling pathways.

Carrier proteins, Transport proteins, Genetic regulation

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Pitx2 determines left-right asymmetry of internal organs in vertebrates

Article Abstract:

The bicoid-related homeodomain transcription factor Pitx2 could be the regulatory force behind the gene network responsible for the morphological events that lead to left-right asymmetries in vertebrates. Pitx2 could interpret and later execute the left-right developmental program dictated by upstream signalling molecules. Pitx2 expression is initiated at the onset of organogenesis and maintained throughout embryogenesis. Its left-right instructive role is required both for the heart and for correct situs of the gut and body rotation.

Vertebrates, Animal anatomy

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