Potential of stem-cell-based therapies for heart disease

Article Abstract:

The clinical science that is forming the foundation of future approaches to cardiac regeneration is examined, given that the reservoirs of progenitor cells present in the heart are not sufficient to replace acute loss of a large number of cells, but would replace a slow apoptotic loss of cells over a lifetime. Attention is also required in immunological issues surrounding rejection if non- autologous sources of stem cells are used.

California, Health aspects, Care and treatment, Genetic aspects, Heart diseases, Apoptosis, Embryonic stem cells

---

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

Article Abstract:

The G-actin sequestering peptide thymosin beta4 that promotes myocardial and endothelial cell migration in the embryonic heart and retains this property in postnatal cardiomyocytes is shown. It is suggested that thymosin beta4 promotes cardiomyocyte migration, survival, and repair and the pathway it regulates may be a new therapeutic target in the setting of acute myocardial damage.

United States, Heart cells, Thymosin

---

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis

Article Abstract:

A demonstration that microRNA-1-1 (miR-1-1) and miR-1-2 are specifically expressed in cardiac and skeletal muscle precursor cells is presented. The results reveal that the miR-1 genes are direct transcriptional targets of muscle differentiation regulators including serum response factor, MyoD and Mef2.

Brief Article, Serum, Blood serum, Genetic transcription, Transcription (Genetics), RNA

Similar abstracts:

• Abstracts: Information content of female chemical signals in the wolf spider, Schizocosa ocreata: Male discrimination of reproductive state and receptivity
• Abstracts: An array of possibilities for the study of autoimmunity. Loss of integrin [[alpha].sub.v][[beta].sub.8] on dendritic cells causes autoimmunity and colitis in mice
• Abstracts: Effects of social organization on inter-clonal dominance relationships in the sea anemone Anthopleura elegantissima
• Abstracts: Generation time and temporal scaling of bird population dynamics. Evolution driven by differential dispersal within a wild bird population
• Abstracts: Hope in the hills for tundra? Parasite rattles diversity's cage. Where slugs may safely graze

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.