PrP and the scrapie agent
Article Abstract:
Two research reports may lead to further study of the protein PrP's role in the pathogenesis of transmissible spongiform encephalopathies. The infectious agent that causes this type of disease, which includes scrapie, has not yet been found. The first report, by Y.G. Xi and colleagues, indicates that PrP is not the agent since the antibiotic amphotericin B slows the disease's progression while allowing protease-resistant PrP to collect in the brain. The second report, by H. Bueler and colleagues, indicates that mice genetically engineered to be without PrP are normal in development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum
Article Abstract:
Endocytosed Shiga protein toxin acts on cytosol by spreading to the trans-Golgi network, to all Golgi stacks, to the endoplasmic reticulum and to the nuclear envelope. Shiga's retrograde transport was demonstrated using butyric acid-treated A431 cells. In addition, the butyric acid also made the cells more sensitive to the Shiga toxin, bearing out the supposition that retrograde transport is necessary for bringing the toxin to the cytosol.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Scrapie control under new strain
Article Abstract:
Scarpie is a fatal brain disease of sheep and goats and is a part of transmissible spongiform encephalopathy family; many countries have established programmes to create disease-resistant national flocks by selective breeding. The European Union (EU) is aiming to eradicate scrapie from its member states by using a combination of two approaches.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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