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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Roles of E. coli DNA polymerases IV and V lesion-targeted and untargeted SOS mutagenesis

Article Abstract:

New research investigates the roles of Escherichia coli DNA polymerases polIV and V in lesion-targeted and untargeted SOS mutagenesis.

Author: Goodman, Myron F., Tang, Mengjia, Pham, Phuong, Shen, Xuan, Taylor, John-Stephen, O'Donnel, Mike, Woodgate, Roger
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
DNA polymerases, Mutagenesis

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A model for SOS-lesion-targeted mutations in Escherichia coli

Article Abstract:

A model is proposed to explain SOS lesion targeted mutagenesis in Escherichia coli.

Author: Goodman, Myron F., Pham, Phuong, Woodgate, Roger, Bertram, Jeffrey G., O'Donnell, Mike
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001

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Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

Article Abstract:

Research reveals that activation-induced cytidine deaminase (AID)-catalyzed cytidine deaminations occur on 5' WRC sequences and 10-70 cytidine to thymine mutaions per clone are observed. AID shows a 15-fold preference for cytidine deamination on the non-transcribed single-stranded DNA.

Author: Goodman, Myron F., Pham, Phuong, Bransteitter, Ronda, Petruska, John
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
United States, Biological Product (except Diagnostic) Manufacturing, Nucleic Acid Derivatives, Genetic aspects, Mutation (Biology), Mutation, Nucleotides, Enzyme activation, DNA synthesis

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Subjects list: Research, Escherichia coli
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