Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion

Article Abstract:

The concept of vaginal microbicide, the application of inhibitory compounds is evaluated using the rhesus macaque 'high dose' vaginal transmission model with a CCR5-receptor-using simian-human immunodeficiency virus (SHIV-162P3) and three compounds that inhibit different stages of the virus-cell-attachment and entry process. Significant protection is achieved using each compound alone and in combinations.

United States, Diseases, Macaques

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Images from the surfaces of HIV

Article Abstract:

The fate of newly produced HIV particles depend on whether protruding structures, or spikes on their surface can make contact with receptors on white blood cells, especially a subset called CD4 T cells. If the viral spikes, which are tripod-like assemblies, make a contact then genetic material of the virus is injected into the target cell and the viral genome starts dictating events in the cell.

California, Genomes, HIV antigens, Structure

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Fc receptor but not complement binding is important in antibody protection against HIV

Article Abstract:

A report on the dramatic decrease in the ability of a broadly neutralizing antibody to protect macaques against SHIV challenge when Fc receptor and complement-binding activities are engineered out of the antibody is presented. Results suggest the potential importance of activity against both infected cells and free virus for effective protection against HIV.

Usage, HIV infection, HIV infections, AIDS vaccines, HIV antibodies

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