Proteomics for the pore
Article Abstract:
Route and colleagues have used proteomoics to reveal the entire molecular architecture of the yeast nuclear port complex. Nuclear pore complexes are large octagonal structures extending over the nuclear envelope of a cell. They influence many signal-transduction and gene-expression pathways. Rout and colleagues identified each of the detectable polypeptides in yeast nuclear pore complexes and each potential component protein within the cell has been systematically localized.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Structure of the nuclear transport complex karyopherin-beta2-ran.GppNHp
Article Abstract:
The prototypic import pathway of Kap-Beta2, which mediates nuclear import of pre-mRNA-binding proteins, has been studied to gain an understanding of the molecular details of nuclear transport. The helical HEAT in Kap-Beta2 form a large surface for interactions, organized into orthogonal and spatially distinct binding sites for GTPase and substrate. The Kap-Beta2 structure is a likely archetype for transport proteins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Microdomains of GPI-anchored proteins in living cells revealed by crosslinking
Article Abstract:
Past research has failed to show whether glycosyl-phosphatidylinositol (GPI)-anchored proteins occur in the cell membrane's microdomains, which have been implicated in several processes, including signal transduction. A new study uses chemical crosslinking to show that GPI-anchored protein exists in microdomains at the surface of living cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A search for human influences on the thermal structure of the atmosphere. Krakatoa's signature persists in the ocean
- Abstracts: Direct measurement of electrical transport through DNA molecules. Room-temperature transistor based on a single carbon nanotube
- Abstracts: US biologists propose launch of electronic preprint archive. Celera in talks to launch private sector human proteome project
- Abstracts: Transgenic trials under pressure in Germany. Germany follows Britain in dumping fast breeder. Germany holds up cultivation of GM maize...