RNA polymerase II is an essential mRNA polyadenylation factor

Article Abstract:

Messenger RNA production in eukaryotic cells is a complicated multi step process. mRNA polyadenylation requires cleavage/polyadenylation-specificity factor (CPSF), cleavage-stimulation factor, two cleavage factors and poly(A) polymerase. The reactions may be linked to be effectively coordinated in vivo. The CTD carboxy-terminal domain of the RNA polymerase II subunit is need to effective splicing. It is suggested that polyadenylation factors can be used by an RNA 3'-processing signal by RNAPII.

Eukaryotic cells, Cells (Biology), Eukaryotes, RNA polymerases, Messenger RNA

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Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock

Article Abstract:

The dephosphorylated SRp38 interacts with a U1 small nuclear ribonucleoprotein particle (snRNP) protein, and that this interaction interferes with 5'-splice-site recognition by the U1 snRNP, is discussed. SRp38-deficient DT40 cells show an altered cell-cycle profile consistent with a mitotic defect; they are also temperature sensitive and defective in recovery after heat shock.

United States, Science & research, RNA splicing, Ribonucleoproteins

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