RNA recognition and translational regulation by a homeodomain protein
Article Abstract:
The homeodomain-containing protein bicoid (bcd) acts as a RNA binding translational repressor and downregulates caudal (cad) protein expression by a post-transcriptional mechanism. The post-transcriptional mechanism depends upon a cis-acting regulatory sequence in the 3' untranslated region (UTR) of the cad mRNA. The bcd attaches to the 3' UTR of cad mRNA by interaction between the homeodomain and the BRE and inhibits a 5' cap-mediated procedure of translational initiation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Sequence specific RNA binding by Bicoid
Article Abstract:
Recent research on the bicoid protein (Bcd) indicates that it is capable of binding messenger ribonucleic acid (RNA) that genetically encodes the caudal protein as well as representing its translation. Certain competition experiments conducted under various conditions have proven that direct, sequence-specific interactions are capable of occurring between the Bcd and a discrete RNA sequence in a certain, untranslated portion of the Cad called the Bcd response element.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Article Abstract:
A new gene, slimb (for supernumerary limbs), is a negative regulator that usually stops activity of the Hh signal transduction pathway in the absence of ligand. Conceptual translation of the open reading frame indicates that slimb encodes a member of the F-box/WD40-repeat family of proteins which includes the yeast cell-cycle proteins Cdc4 and Pop1. It is possible that the mammalian homologues of slimb are tumour-suppressor genes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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