Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

Article Abstract:

A mouse model is used, where endogenous Foxp3 gene expression is attenuated in regulatory T cells ([T.sub.R]), to show that decreased Foxp3 expression enables the development of an aggressive autoimmune syndrome, but does not affect thymic development and homeostatic expansion. The results have shown that decreased Foxp3 expression causes immune disease by subverting the suppressive function of [T.sub.R] cells and converting [T.sub.R] cells into effector cells.

Connecticut, Analysis, Causes of, Risk factors, Body temperature, Body temperature regulation, Gene expression, X chromosome, Immunologic diseases

---

A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

Article Abstract:

The genomes of four wild-derived and eleven classical strains are resequenced and 8.27 million high-quality single nucleotide polymorphisms (SNPs) densely distributed across the genome are identified. The regional redundancy of the SNP data has facilitated imputation of the majority of the genotypes in less-densely typed classical inbred strains.

Nucleotide sequence, Base sequence, Genetic research, Single nucleotide polymorphisms

---

Similar abstracts:

• Abstracts: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Immunological agnosia
• Abstracts: The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. A constraint on canonical quantum gravity?
• Abstracts: Regulation of the bacterial cell cycle by an integrated genetic circuit. Non-mitochondrial complex I proteins in a hydrogenosomal oxidoreductase complex
• Abstracts: Factors preventing the recovery of New Zealand forests following control of invasive deer. Climatic Suitability, Life-History Traits, Introduction Effort, and the Establishment and Spread of Introduced Mammals in Australia
• Abstracts: Red snow: algae blooms are winter's final celebration. Seagoing spaceships. Wine and wildlife

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.