Relaxation of imprinted genes in human cancer
Article Abstract:
A study of genomic imprinting in humans is presented. Genomic imprinting is the parental allele-specific expression of genes and has been demonstrated at the molecular level in insects and mice. Paternal uniparental disomy of 11p15 in Beckwith-Wiedemann syndrome and maternal uniparental disomy of 15q11-12 in Prader-Willi syndrome suggest that genomic imprinting may be a potential mechanism for pathogenesis in humans. Analysis of DNA from kidneys of normal individuals and Wilms' tumor patients showed that relaxation or loss of imprinting could be one mutational mechanism for carcinogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Phenotypic plasticity and the epigenetics of human disease
Article Abstract:
The epigenetics of single-gene disorders, cancer and common complex diseases are discussed. Epigenetics have helped in understanding the role of the environment's interactions with the genome in causing disease and in modulating those interactions to improve human health.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Article Abstract:
A study to examine the epigenetic silencing of the tumor suppressor gene (TSG) p15 by its antisense RNA is conducted. Results show that the natural antisense RNA helps in facilitating the heterochromatin formation in TSG silencing in tumorigenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
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