Requirement for IRF-1 int he microenvironment supporting development of natural killer cells
Article Abstract:
Natural killer (NK) cells are crucial for both innate and adaptive immunity and their development requires interactions between their progenitors and the bone marrow. The molecular nature of such interactions is not well known. It is now demonstrated that the lack of interferon-regulatory factor-1 (IRF-1) has an affect on radiation resistant cells constituting the environment needed for NK-cell development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage
Article Abstract:
Embryonic fibroblasts lacking interferon regulatory factor (IRF)-1 and the tumour suppressor p53 are unable to undergo cell-cycle arrest in response to DNA damage, although the expression of both is independent of one another. The two transcription factors converge functionally in encoding p21, a cell-cycle inhibitor, and thus control the cell cycle through the stimulation of common target genes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
Article Abstract:
Interferon regulatory factor (IRF)-1 appears to be a tumor suppressor whose inactivation may be linked with myelodysplastic syndrome and leukemia development. There may be two different DNA damage-induced apoptosis pathways for T lymphocytes. IRF-1 appears to function in mitogen-stimulated mature T lymphocytes while the previously accepted p53 pathway functions in thymocytes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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