Retinoblastoma protein represses transcription by recruiting a histone deacetylase
Article Abstract:
Cell proliferation is inhibited by the retinoblastoma tumour-suppressor protein Rb, through the repression of genes controlled by E2F transcription factors. Rb masks the E2F1 transactivation domain and inhibits surround enhancer elements. It is shown that HDAC1, a histone deacetylase, interacts and cooperates with Rb, and the sequence involved is an LXCXE motif, suggesting that the Rb/HDAC1 complex plays an important role in the control of cell proliferation and differentiation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals
Article Abstract:
The distribution of macroH2A (mH2A) in mouse liver nuclei was examined by immunofluorescence, using non-histone antibodies of the mH2A subtypes, mH2A1.2. speckled staining was seen through most of the nuclei in both males and females, although the nuclei of females had large and distinct mH2A-dense regions, named macrochromatin bodies (MCBs). MCBs were detected using tissue fixation and polyclonal antibodies.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
Article Abstract:
Research shows that deoxyribonucleic acid (DNA) dependent protein kinase acts as an intermediary in the DNA damage physiological pathway which results in tumour suppressor p53 gene expression. Gene activation is caused following DNA damage through p53 sequence-specific DNA binding. Experiments using BALB/c 3TS and SCGR11 cells and cell-free in vitro translation techniques are described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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