Rhomantic interludes raise blood pressure: Signal transduction
Article Abstract:
Narumiya and colleagues have described a drug that can reduce the activity of an enzyme sensitizing smooth-muscle contraction to Ca2+. The new drug has reduced high blood pressure in experimental animals. The results shed new light on a signalling system operating in smooth muscle and in non-muscle cells. The new work has increased the possibilities of finding causes of and treatments for diseases caused by abnormalities of smooth-muscle contraction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Activation of Raf by ionizing radiation
Article Abstract:
Ionizing radiation stimulates protein-tyrosine kinase, which in turn modifies Raf-1, a cytoplasmic serine-threonine protein kinase. Raf-1 is further implicated in the ionizing-radiation signal-transduction pathway. The overexpression and activation of Raf-1 enhances the survival response of mammalian cells to the toxic ionizing radiation effects. A model of irradiation-responsive signal transduction pathway is proposed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Marked for nuclear export?
Article Abstract:
Genetic research suggests that eukaryote cell cycle regulation depends upon the presence of signal transducer nuclear diacylglycerol (DAG). Scientists Topham et al have proposed a hypothetical model for nuclear DAG regulation. Further research is required to determine the exact nature of catalytic enzyme reactions during nuclear DAG metabolism.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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