Role of inscuteable in orienting asymmetric cell divisions in Drosophila
Article Abstract:
The asymmetric localization of the inscuteable gene product regulates spindle orientation during interphase and asymmetrically localizes the Numb and Prospero proteins during Drosophila cell division. In mutants lacking inscuteable, neuroblasts divide randomly while the procephalic neurogenic region (PNR) epithelial cells divide parallel to the surface. The PNR cells are unable to rotate their mitotic spindles, and asymmetrically localize Numb and Prospero. The ectopic expression of inscuteable in ectodermal cells outside the PNR reorients the mitotic spindle.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
DNA renaturation activity of the SMC complex implicated in chromosome condensation
Article Abstract:
Chromosome condensation in mitosis requires DNA topoisomerase II and SMC proteins. SMCs are also needed for the separation of sister chromatids and gene dosage compensation. The chromosomes in fission-yeast SMC mutants were studied and the proteins Cut3 and Cut14 were tested for their role in DNA condensation. DNA renaturation reactions were efficiently promoted, implicating the SMC complex in promoting higher order DNA coiling found in condensed chromosomes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Cytoskeleton in the cell cycle
Article Abstract:
Issues are presented concerning the checkpoints which occur during the division of cells. The discovery of a checkpoint which specifically monitors the organization of the actin cytoskeleton is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Test of synergistic interactions among deleterious mutations in bacteria. A viable herd of genetically uniform cattle: Deleterious alleles seem to have been purged in a feral strain of inbred cows
- Abstracts: Essential role for Gab2 in the allergic response. Phosphorus solubilization in rewetted soils. Pasteur's quadrant and malnutrition
- Abstracts: Quantum interference in a mesoscopic superconducting loop. Organic superconductivity grows in high fields. Superconducting plastic
- Abstracts: Bullets or fragmenting shells? Gravitational waves constrained
- Abstracts: Geochemistry of mantle-core differentiation at high pressure. Mantle cookbook calibration