Knockout malaria vaccine?

Article Abstract:

A genetically manipulated malaria parasite can be used as an effective vaccine against malaria. An avium Plasmodium system was used to prevent erythrocyte infection because it was found that immunization with irradiated sporozoites could prime the immune system to target normal sporozoites.

Prevention, Malaria, Immunization

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Genetically modified Plasmodium parasites as a protective experimental malaria vaccine

Article Abstract:

Reverse genetics is used to show that one identified gene, UIS3 (regulated in infective sporozoites gene 3), is necessary for early liver-stage development. The results show that a safe and effective, genetically attenuated whole-organism malaria vaccine can be developed experimentally.

Genetic aspects, Plasmodium, Plasmodium (Protozoa)

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