Self-assembly of organic films on a liquid metal

Article Abstract:

Densely packed self-assembled monolayers of alkanethiol films on the surface of liquid mercury form strong chemical bonds to the subphase. Synchrotron X-ray scattering reveals that the subphase is smooth and unstructured like Langmuir monolayers. These films lack interplane long-range order. This is due to the strong reactions of the thiol group with the underlying disordered liquid, which suppresses the order-promoting interactions of the alkyl chains.

Analysis, Observations, Organic compounds, Monomolecular films, Liquid metals

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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

Article Abstract:

Acquired immunodeficiency syndrome (AIDS) develops when a host's CD4 lymphocytes are destroyed by the human immunodeficiency viruses HIV-1 and HIV-2. Viral envelope glycoproteins gp120 and CD4 mediate the HIV's entry into host cells. A new study investigates the structure of gp120, which reveals some surprising features, including a cavity-laden CD4-gp120 interface and a natural mechanism for receptor-induced conformational changes.

Models, Genetic aspects, Glycoproteins, AIDS (Disease), Immunological research, Immunologic research, HIV antibodies

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Structural basis of cell-cell adhesion by cadherins

Article Abstract:

The atomic level of certain types of adhesive cell contact between cells is revealed by studying the crystal structure of the amino-terminal domain of N-cadherin. The study reveals the presence of a repetitive set of dimer interfaces that are common to the structure found in three lattices. A linear zipper structure of molecules is formed by these interaction. This zipper structure is responsible for the adhesive features.

Cell adhesion

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