Sequence-specific DNA binding by Ku autoantigen and its effects on transcription

Article Abstract:

DNA-dependent protein kinase (DNA-PK) binding to DNA at the high affinity negative regulatory element 1 (NRE1) represses the glucocorticoid-initiated mouse mammary tumour virus (MMTV) transcription. Ku autoantigen was used as a transcription factor in this binding. NRE1 is a DNA sequence element (-394/-381) present in the long terminal repeat of MMTV. Glucocorticoid receptor and octamer transcription factor are important DNA-PK targets, responsible for the regulation of MMTV transcription.

Physiological aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), DNA binding proteins, Antigens

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Confirmational change

Article Abstract:

The crystal structure of a partially active cyclin A-CDK2 complex confirms the predictions that the confirmational changes introduced by cyclin binding would induce the kinase to activate. The interaction between cyclin and the T-loop's amino-terminal portion of T-loop, also causes the T-loop to move away from the active side, thus stabilizing its position through ionic interactions. The structure of cyclin before it binds is still an unsolved problem.

Analysis

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