Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands
Article Abstract:
It has been possible to use the crystal structure of the B5 subunit of Escherichia coli 0157:H7 Shiga-like toxin I (SLT-I) in complex with an analogue of its carbohydrate receptor to design an oligovalent, water-soluble carbohydrate ligand. This ligand, designated STARFISH, has subnanomolar inhibitory activity. The STARFISH inhibitor was shown to protect susceptible cells against prolonged exposure to SLT-I and to the apparently more clinically significant SLT-II, a toxin for which there were previously no inhibitors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Replication of a cis-syn thymine dimer at atomic resolution
Article Abstract:
Two crystal structures of Dpo4, an archael pol eta homologue, are determined, which are complexed with CPD-containing DNA, where the 3' and 5' thymine of the cyclobutane pyrimidine dimers (CPD) separately serves as a templating base.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Structure of a serpin-protease complex shows inhibition by deformation
Article Abstract:
Serpin-protease complex structure shows inhibition by deformation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Charge separation in localized and delocalized electronic states in polymeric semiconductors. Efficient photodiodes from interpenetrating polymer networks
- Abstracts: UK's physical scientists are left disappointed by budget choices. Gunfire echoes in debates on public understanding
- Abstracts: Sex roles, parental experience and reproductive success of eastern kingbirds, Tyrannus tyrannus. The detection of and responses to experimental intraspecific brood parasitism in eastern kingbirds
- Abstracts: The toad in the rearview mirror. Of violence and popcorn. Conversations with no one
- Abstracts: Pictures, words and the brain. The brain's dictionary. Separable processing of consonants and vowels