Shigella flexneri induces apoptosis in infected macrophages

Article Abstract:

Infection of macrophages by the Gram-negative pathogenic bacterium Shigella flexneri (S. flexneri) can result in macrophage apoptosis or programmed cell death. Tests of the murine macrophage cell line J774 in an ordinary C-release assay determined the cytotoxicity of S. flexneri, which produces a form of dysentery called shigellosis. Invasive strains of S. flexneri generated apoptosis while noninvasive and mutant strains did not. This is the first demonstration that invasive, disease-causing bacteria can cause infected cells to self-destruct.

Infection, Physiological aspects, Macrophages, Shigella flexneri, Shigellosis, Bacillary dysentery

---

A candidate gene for the mouse mutation tubby

Article Abstract:

Research on late onset obesity in mice with a mutation in the tub gene has led to the identification of a G to T transversion in a candidate gene. The donor splice site in the 3' coding region is destroyed by the transversion which produces a larger transcript containing the unspliced intron. In addition, another prematurely truncated transcript with the unspliced intron is observed in testis messenger RNA. The mutated gene may trigger apoptosis in retinal and neurosensory tissue, explaining the other symptoms in tubby mice.

Gene expression, Mutation (Biology), Mutation, Obesity gene

---

Rips repaired

Article Abstract:

The degenerative muscle disease is the defect in muscles cell as a result of many suffering tiny membrane ruptures that damage the cells internally. The compound protein dytrophin is the essential link in the complex structure of cell protein that increases the resealing of cell membrane and protects heart muscles from these effects.

United States, Science & research, Muscle diseases, Muscular diseases, Heart muscle, Myocardium

Similar abstracts:

• Abstracts: The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. A Grb2-associated docking protein in EGF- and insulin-receptor signalling
• Abstracts: Proximate and ultimate causes of adoption in ring-billed gulls. Deciding where to settle: conspecific attraction and web site selection in the orb-web spider Nephilengys cruentata
• Abstracts: Male mating tactics in the horseshoe crab, Limulus polyphemus. Why do male crab spiders drink nectar?
• Abstracts: Incipient reproductive isolation and evolution in laboratory Drosophila melanogaster selected for geotaxis. Size-assortive mating in Drosophila malerkotliana
• Abstracts: Private industrial forests and bird conservation in the northeastern United States. The boulder darter: a conservation challenge

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.