Signatures guide drug choice

Article Abstract:

The issue of predicting the best treatment for a particular tumour is addressed in different ways and a potential strategy is given for deciding the most effective combination of therapies based on the gene expression signature of a tumour. From a single microarray, it should be possible to determine the extent to which different signalling pathways are activated and what combination of pathway-specific drugs might be most effective.

Science & research, Care and treatment, Gene therapy, Tumors, Tumours, Serial analysis of gene expression

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New exchange, new target

Article Abstract:

The Ras guanine-nucleotide-binding (G) family of proteins controls cellular behaviour such as proliferation, survival, morphology and membrane transport. Their common mechanism is the opposing effect of stimulatory guanine-nucleotide-exchange factors (GEFs). Researchers have made a study showing control of Ras family proteins is more varied than thought and provides molecular information on that control.

Observations, Proteins, Ras genes

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The ins and outs of signalling

Article Abstract:

The key issues relating to biological signalling, including specificity and signal integration, are discussed. The availability of full genome sequences will have a very significant impact on scientists' understanding of the signalling pathways.

Analysis, Cell interaction

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