Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

Article Abstract:

Research examining the ways in which drugs of abuse modify neural circuits and induce addiction is presented. Particular attention is given to experimental demonstrations of the way in which a single dose of cocaine can induce long-term potentiation of dopamine neurons.

Cocaine abuse, Drug abuse, Dopamine receptors, Drug synergism

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A critical period for long-term potentiation at thalamocortical synapses

Article Abstract:

A research study proposed that correlated pre- and postsynaptic activity fortifies synaptic connections. N-methyl-D-aspartate receptor-dependent long-term potentiation (LTP) is also proposed as a likely mechanism for the correlated pre- and postsynaptic process. However, the involvement of LTP in normal development has not been fully established. Results of the study prove that LTP is vital to the development of cortical circuitry.

Mammals, Cerebral cortex, Thalamus

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Contrasting properties of two forms of long-term potentiation in the hippocampus

Article Abstract:

Analysis of two different forms of long-term potentiation in the hippocampus revealed that N-methyl-D-Aspartate-receptor are present at various excitatory synapses in the hippocampus and many synapses in the brain. No evidence for the involvement of the mossy fibre synapses in long-term potentiation was found in the studies. One form involves activation of the NDMA subtype of glutamate receptor and an increase in postsynaptic calcium ion. The other form, observed in mossy fibre synapses, requires increases in calcium ions and is independent of NMDA.

Analysis, Physiological aspects, Brain chemistry

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