Spatial calcium buffering in saccular hair cells

Article Abstract:

Hair cells in frog sacculus have minute concentrations of mobile cytoplasmic calcium buffer that catches Ca2+ after it passes the presynaptic Ca2+ channels. Presynaptic free Ca2+ is lowered by 60 percent owing to spatial buffering. The buffer modifies the electrical resonance and synaptic transmissions. Calbindin-D28K or a related protein may function as mobile calcium buffers, an action analogous to conveying Ca2+ across intestinal epithelial cells. Mobile Ca2+ is likely to have significance in terms of electrical modulation and synaptic transmission in hair cells.

Calcium channels, Membrane potentials, Membrane potential

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Zapping tandem SH2 domains

Article Abstract:

The binding of two ZAP-70SH2 domains to a doubly phosphorylated ITAM creates a coiled-coil loop, via high-affinity binding of ZAP-70 to an ITAM. The coiled-coil loop consists of 65 residues and contributes in stabilizing the SH2-SH2 interaction. Stabilization effect also appears due to surface interactions of SH2 domains with the ITAM. Different patterns of zeta-chain phosphorylation in these interactions are discussed.

Protein tyrosine kinase, Protein-tyrosine kinase, Phosphorylation

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Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination

Article Abstract:

A mathematical model describing the dynamics of the Notch signalling pathway during chick embryo gastrulation, which reveals a complex and highly robust genetic network that locally activates Notch on the left side of Hensen's node is presented.

United States, Science & research, Vertebrates, Embryology, Experimental, Embryological research, Gastrulation

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