Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins

Article Abstract:

Drosophila Hox proteins that are expressed in Caenorhabditis elegans homologues, are substitutable for C. elegans Hox proteins, Scr and Antp, in the control of three different cell-fate decisions, despite significant differences in the homeodomains. The decisions are: the specification of sensory structure, the regulation of cell migration, and the specification of serotonergic neurons. The specificity of one C. elegans Hox protein can also be determined by two amino acids which are implicated in sequence-specific DNA binding. The compatibility between the Hox proteins of C. elegans, vertebrates and Drosophila indicate widespread conservation.

Genetic aspects, Homeobox genes, Serotoninergic mechanisms, DNA binding proteins

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AC. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division

Article Abstract:

The Caenorhabditis elegans gene cam-1 is shown to encode a member of the Ror kinase family guiding migrating cells. Tyrosine kinase activity is needed for certain functions of CAM-1, although not for its role in cell migration. Overexpression and loss of cam-1 leads to reciprocal cell-migration phenotypes, suggesting that levels of CAM-1 have an effect on the final position of migrating cells.

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A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

Article Abstract:

Research is presented concerning the coordinated cell migration which occurs during organogenesis of the heart in the normal and the miles apart mutant forms of the Zebrafish. The role of sphingosine-1-phosphate in the process is discussed.

Fishes, Embryology, Animal embryology, Animal development

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