Specificity domains distinguish the Ras-related GTPases Ypt1 and Sec4

Article Abstract:

The structural basis for the stage-specific actions of the Ras-related GTPases Ypt1 and Sec4 during secretion by Saccharomyces cerevisiae was investigated. Ypt1 is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus, while Sec4 is involved in the fusion of post-Golgi vesicles with the cell membrane. The study involved the development of Ypt1/Sec4 chimeras. The results revealed the presence of specificity domains which confer Ypt1 or Sec4 activities.

Composition, Secretion, Physiological regulation, G proteins

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Ion-channel studies blossom

Article Abstract:

A new class of artificial ion channels has been constructed by grafting poly(oxyethylene) or polymethylene chains of various lengths onto macrocyclic rings. The resulting compounds are termed 'bouquet' molecules, of which two types have been tested. Experiments using artificial lipid vesicles showed that the bouquet molecules, when inserted within the lipid bilayer, could facilitate the rapid interchange of alkali metal atoms between the interior of the cell and the exterior.

Design and construction, Ion channels

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Tuning retinal circuits

Article Abstract:

Gap junctions, clusters of fine intracellular channels in the retina, have different pore sizes at different points of the retinal circuit, and they are regulated by different second messengers. This is revealed in an in-vitro study of transport of tracers having different molecular weights in the retinal cells of rabbits. Results suggest reversible nature of the AII-cone bipolar junction.

Analysis, Physiological aspects, Retina, Neural conduction

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