Sperm chromatin proteomics identifies evolutionary conserved fertility factors

Article Abstract:

Proteomics, cytology and functional analysis are combined in Caenorhabditis elegans to identify spermatogenic chromatin-associated proteins that are important for fertility. The strategy to find fertility factors conserved from C. elegans to mammals achieved its goal of obtaining mouse gene knockouts corresponding to nematode proteins and hence the list provides significant opportunity to identify causes of male infertility and targets for male contraceptives.

Chromatin, Caenorhabditis elegans, Spermatozoa, Sperm, Proteomics

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Social interactions among epithelial cells during tracheal branching morphogenesis

Article Abstract:

Genetic mosaic analysis in Drosophila melanogaster is used to show that there are two functionally distinct classes of cells in budding tracheal branches. These classes are the cells at the tip that respond directly to Branchless fibroblast growth factors (FGF) and lead branch outgrowth, and trailing cells that receive a secondary signal to follow the lead cells and form a tube.

United States, Analysis, Physiological aspects, Genetic aspects, Epithelial cells, Drosophila, Morphogenesis

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