Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
Article Abstract:
Mice lacking matrix GLA protein (Mgp) exhibit inappropriate arterial and cartilage calcification. Mgp, a mineral-binding extracellular matrix protein, is synthesized by vascular smooth-muscle cells and chondrocytes. Mgp-deficient mice develop to term but die within two months. Autopsies revealed that the cause of death was hemorrhage due to blood-vessel rupture. Phenotypic abnormalities in Mgp-deficient mice indicate that Mgp inhibits calcification of certain ECMs via its mineral-ion-binding ability.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
Article Abstract:
Lysine-specific demethylase 1 (LSD1) co-localizes with the androgen receptor in normal human prostate and prostate tumor. Demethylation of a repressive histone mark with androgen-receptor-dependent gene activation is linked thus providing a mechanism by which demethylases control specific gene expression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Genetic ablation of parathyroid glands reveals another source of parathyroid hormone
Article Abstract:
Research is presented concerning the existence of an auxiliary mechanism for calcium homeostasis regulation when parathyroid glands are absent. The use of this mechanism for endocrine regulation is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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