V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling

Article Abstract:

Immune tolerance during B-cell development in the bone marrow is controlled by receptor editing, followed by the induction of apoptosis. The frequencies of B cells expressing the immunoglobulin Lambda light (L) chain have been monitored. Isolated B cells were treated with interluekin-4 (IL-4) and lipopolysaccharide (LPS), which led to an eightfold increase in the number of Lambda+ B cells relative to control culture, but just a twofold rise in B-cell recovery. Predictions that stimuli inducing Lambda expression increase V(D)J recombinase activity were tested and it was found that immune tolerance is unlikely to induce V(D)J recombination in mature B cells.

B cells, Lymphocytes, Immunological tolerance, Immunologic tolerance

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Integrin cytoplasmic tyrosine motif is required for outside-in allbB3 signalling and platelet function

Article Abstract:

An experiment with mice gives proof of the importance of outside-in signalling in platelet physiology. It also shows that the integrin cytoplasmic tryosine motif mediates B-integrin signals and targets new therapeutic agents. A mouse which expresses an aIIbB3 with the tyrosines in the integrin cytoplasmic tyrosine motif changed to phenylalanines shows a tendency to bleed again and again.

Blood platelets

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