Structural basis of long-term potentiation in single dendritic spines
Article Abstract:
A study is conducted to examine the structural basis of long-term potentiation using two-photon photolysis of caged glutamate at single spines of hippocampal CA1 pyramidal neurons. The findings indicate that repetitive quantum-like photorelease of glutamate induce rapid and selective enlargement of stimulated spines that is transient in large mushroom spines but persistent in small spines.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Structure and different conformational states of native AMPA receptor complexes
Article Abstract:
The structure of native AMPA receptors purified from rat brain, as determined by single-particle electron microscopy is presented. The data provides a glimpse of the conformational changes of an important ligand-gated ion channel of the brain.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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