Suppression of psychoactive effects of cocaine by active immunization

Article Abstract:

The suppression of psychoactive effects of cocaine is possible by active immunization providing a possible therapy for cocaine abuse. Immunization with a stable cocaine conjugate suppresses locomotor activity and stereotyped behavior, stimulated by cocaine, in rats. The levels of cocaine in the striatum and cerebellum are lower in immunized rats. An active immunogen inhibits the action of the drug by preventing its entry into the central nervous system. The preparation of a cocaine immunogen necessitates attention on the stability of free cocaine and as a haptenic determinant.

Care and treatment, Complications and side effects, Physiological aspects, Drug therapy, Drug addicts, Drug abusers, Cocaine abuse, Psychotropic drugs, Immunization

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Cationic cyclopropanation by antibody catalysis

Article Abstract:

The problems associated with controlling the conformation and chemical environment of carbocaton intermediaries hinder efforts to maximize the potential for directing the pathways of cyclization reactions to generate energetically unpopular products. It is demonstrated that antibody catalysts can be used to gain conformational and chemical control needed to keep such reactions in check, and to maintain selective control over cationic cyclization reactions to create products that would otherwise be disfavored.

Analysis, Catalysis, Antibodies

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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Article Abstract:

The enzyme oleamide hydrolase is responsible for the inactivation of neuromodulatory fatty acid amides, bioactive signalling molecules. The protein sequence of the fatty-acid amide hydrolase (FAAH) has similarities with the protein sequence of the various amidase enzyme sequences taken from divergent organisms. These different amidases share a common identifying sequence. The FAAH cDNA transfected COS-7 cells show high activity levels of oleamide hydrolase.

Research, Observations, Enzymes, Amino acid sequence, Amino acid sequencing

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