Synaptic vesicles retain their identity through the endocytic cycle

Article Abstract:

Vesicular membrane internalization occurs after the synaptic vesicles and presynaptic membrane fuse and the contents of vesicles are secreted into the synaptic cleft. However, several issues regarding internalization remain puzzling, including the location of membrane retrieval. The classic model suggests that internalized vesicles communicate with intermediate endosome-like compartments during recycling, but a new study uses the fluorescent membrane dye FM1-43 and quantitative fluorescent microscopy to show that this picture may be flawed.

Neurobiology, Neural transmission, Synaptic transmission, Exocytosis

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The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

Article Abstract:

Electrophysiological study of neurotransmitter release in mice with Rab3A protein deficiency is used to identify the exact point of action by Rab3A in the synaptic vesicle docking and fusion process. The readily releasable vesicles pool is shown to be surprisingly normal. However, fusion triggered by Ca2+ is transformed when Rab3A is not present, with an unusually high number of exocytic events happening shortly after the nerve impulse arrives.

Usage, Electric properties, Carrier proteins, Transport proteins, Cell membranes, Letter to the Editor, Electrophysiology, Rodents as laboratory animals, Laboratory rodents

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An evolutionary scaling law for the primate visual system and its basis n cortical function

Article Abstract:

Research exploring the importance of size in the evolution of the neocortex of mammalians is presented, with particular focus on the visual system in primates. Comparisons between the number of neurons in the visual thalamus and area V1 are carried out.

Evolution (Biology), Visual perception, Cerebral cortex, Primates, Anatomy

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