Synthesis of RNA oligomers on heterogeneous templates
Article Abstract:
Heterogeneous oligocytidylates, formed by either the montmorillonite clay-catalyzed condensation of actuated monomers or by any other chemical process, could be attributed for the formation of complementary oligomers on Earth. Aside from their ability to function as templates for the synthesis of oligoguanylates, oligocytidylates that are exclusively 2', 5'-linked can even direct the synthesis of oligoguanylates. These templating reactions may have increased the diversity of the pool of protonucleic acids which ultimately resulted in the formation of life.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Synthesis of long prebiotic oligomers on mineral surfaces
Article Abstract:
Mineral surfaces may allow formation of long prebiotic oligomers containing up to 55 monomers. The minerals are incubated with an activated monomer till small oligomers are formed. The oligomers are removed by centrifugation and the monomers are replaced onto the minerals. Repeated feedings with the monomers result in polymerization on the mineral surfaces in a way similar to that of solid-phase synthesis of biopolymers. The mineral montmorillonite catalyzes the formation of nucleotides and the minerals illite and hydroxyapatite catalyze of amino acids.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Oxidative acylation using thioacids
Article Abstract:
Many prebiotic reactions involve acylation, and the use of thioacids as acylating agents has been extensively studied. A closely related route to amide bond formation involving oxidative acylation by thioacids is proposed, showing that phenylalanine, phenylphosphate and leucine are efficiently acylated in aqueous solution by thioacetic acid together with an oxidizing agent.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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