Telomerase activation by the E6 gene product of human papillomavirus type 16
Article Abstract:
Telomerase was shown to be activated by the human papillomavirus type 16 (HPV 16) E6 proteins. This was determined using newly infected, early-passage human foreskin keratinocytes (HFK), human mammary epithelial cells (HMEC), and human fibroblasts. Observations indicated prompt telomerase activation in E6-expressing cells in both HFK and HMEC. This suggested that the activation was only applicable to certain cell types. Telomerase activation was also determined to be separate from E6-effected p53 degradation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Structural basis of calcium-induced E-cadherin rigidification and dimerization
Article Abstract:
Cadherins facilitate cell adhesion and are involved in normal development. They take part in the supporting proper cell-cell contacts. Cadherins are composed of five tandemly repeated extracellular domains, one membrane-spanning segment and a cytoplasmic area. They are dependent on calcium to be able to function. The x-ray crystal structure at 2.0A resolution of the two N-terminal extracellular domains of E-cadherin with calcium is presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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A protective role for protease-activated receptors in the airways
Article Abstract:
Prostanoid prostaglandin E2 (PGE2) protects cells in the upper intestine against digestion by pancreatic trypsin. PAR2 is a major source of PGE2 and it was reasoned that bronchial epithelial PAR2 is involved in prostanoid-dependent cytoprotection in the airways. The activation of PAR2 is found to result in the relaxation of airway preparations from mouse, rate, guinea-pig and humans, through the release of cycloxygenase from the epithelium.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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