Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Article Abstract:

Genetic research shows that the newly-identified gene klotho is responsible for controlling the ageing process in mice. Experiments using transgenic founder mice demonstrate that the absence of klotho, a membrane protein, causes reduced longevity, arteriosclerosis, osteoporosis and other conditions normally associated with the ageing process in human beings. Evidence suggests that klotho may have a signalling function which promotes growth.

Age factors in disease, Disease age factors

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A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

Article Abstract:

Research shows that a genetic mutation of organism Caenorhabditis elegans, mev-1(kn-1), impacts the cellular aging process. Experiments using transgenic nematode animals to demonstrate oxidative stress and ageing are described. Mev-1 nematodes cannot catalyze electron transport chain biochemical reactions. Succinate dehydrogenase activity measurements in mev-1 nematodes are compared to those in wild-type nematodes.

Nematoda, Nematodes

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